Case Studies

Efficient Analytical Validation Using Britest Visualisations As Protocols

Protocols for Liquid Chromatography method validations under GMP often require complex dilution schemes with many opportunities for errors in execution. This necessitates inefficient extra checks, and duplication of work (further consuming valuable API). Presenting the dilution schemes visually using a Britest ‘Rich-PrISM’ has made the dilution schemes far easier for analysts to follow. The

Mapping the Manufacturing Value Stream to Spot Improvement Opportunities

Mapping the Manufacturing Value Stream to Spot Improvement Opportunities When the technical team responsible for a market-leading medicine within a high-profile global, science-led biopharmaceutical company wanted to establish where process improvement opportunities existed for the product line, they turned to a Britest study to summarise process inputs, outputs and key information. The study

- OPERATIONAL EXCELLENCE - WHOLE PROCESS UNDERSTANDING Pharma Process Improvement TOOL - Process Information Summary Map

Optimising Plant Changeover / Cleaning Processes

A Britest methodology to support the optimisation of changeover/cleaning processes was used to help FUJIFILM Imaging Colorants address capacity constraints. Improvements to significantly time-consuming steps, and opportunities for improvements to existing CIP equipment were identified, along with a more ambitious opportunity to reduce the cleaning cycle time from 2-3 days to 12 hours through

- EFFECTIVE COLLABORATION - TECHNICAL FACILITATION Process Efficiency Process Improvement Speciality Chemicals TOOL - Process Information Summary Map TOOL - Rich Pictures

Increasing Production of a Speciality Chemical by 50% to meet demand

Increasing Production of a Speciality Chemical by 50% to meet demand This case study describes how a Britest study enabled an internal cross-functional team at Robinson Brothers Limited to rapidly identify and implement process changes designed to improve efficiency and up time, making it possible to support extra sales of ~£1M p.a. Download 'Increasing Production of a Speciality

- WHOLE PROCESS UNDERSTANDING Process Design Process Efficiency Process Improvement TOOL - Process Information Summary Map

Britest Improvement Study to Increase Throughput by 50%

Britest Improvement Study to Increase Throughput by 50% This case study describes the elements of a Britest throughput improvement study carried out by a custom synthesis manufacturer to meet an identified customer need to increase process throughput by at least 50% within three years, which was successfully delivered by halving batch times. Download 'Britest improvement study to increase

- OPERATIONAL EXCELLENCE Custom Manufacture Process Design Process Improvement TOOL - Driving Force Analysis TOOL - Initial Screening Analysis TOOL - Process Definition Diagram TOOL - Process Information Summary Map TOOL - Rich Pictures TOOL - Transformation Map

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